3-Buten-2-ol, 1-[(4,8-dimethoxyfuro[2,3-b]quinolin-7-yl)oxy]-3-methyl-, (-)-
Evodine
CAS: 6989-38-4
Molecular Formula: C18H19NO5
3-Buten-2-ol, 1-[(4,8-dimethoxyfuro[2,3-b]quinolin-7-yl)oxy]-3-methyl-, (-)- - Names and Identifiers
3-Buten-2-ol, 1-[(4,8-dimethoxyfuro[2,3-b]quinolin-7-yl)oxy]-3-methyl-, (-)- - Physico-chemical Properties
| Molecular Formula | C18H19NO5 |
| Molar Mass | 329.35 |
| Density | 1.245 |
| Melting Point | 153-154 ºC |
| Boling Point | 507.0±50.0 °C(Predicted) |
| pKa | 13.26±0.20(Predicted) |
| Physical and Chemical Properties | Density: 1.245 Melting Point: 153-154°C Boiling Point: 507°C at 760 mmHg |
3-Buten-2-ol, 1-[(4,8-dimethoxyfuro[2,3-b]quinolin-7-yl)oxy]-3-methyl-, (-)- - Reference Information
| Overview | Ruodiamine lactone, also known as Ruodipine and limonin, is a white powdery substance extracted from the seeds and pericarps of Rutaceae plants, and it tastes bitter. Evodiamine lactone is one of the effective components of the traditional Chinese medicine Evodia rutaecarpa. It has anti-tumor, anti-inflammatory, antioxidant and inhibition of P-glycoprotein activity. |
| Evodia rutaecarpa plant extract | Evodia rutaecarpa, also known as Evodia rutaecarpa bitter, is a kind of limonin compound extracted from the fruit of Rutaceae Evodia rutaecarpa, colorless crystal (dichloromethane-isopropanol or acetic acid),mp.297 ℃ ~ 298 ℃ (decomposition),[α]D-128 (C = 1.21, acetone). Bitter, slightly soluble in water and ether, soluble in ethanol and glacial acetic acid. The Rutaceae plant Evodia is mainly produced in Guizhou, Guangxi, Hunan, Yunnan, Sichuan, southern Shaanxi and Zhejiang. The output of Guizhou and Guangxi is relatively large, and the quality of the products in Changde, Hunan is good. From July to October, the fruit will be harvested when it is nearly ripe and green. If it is too early, it will be tender, and if it is too late, the fruit will crack, which is not suitable. After picking the fruit, spread it out in the sun or dry it, and remove the stems and impurities. Evodia is spherical or slightly pentagonal oblate, with a diameter of 2 ~ 5mm. The surface is dark yellow-green to brown, rough, with many punctate protrusions or concave oil spots. There are five-pointed star-shaped fissures at the top, and yellow fuzz stems remain at the base. Hard and brittle, 5 chambers of ovary can be seen in cross section, and 1~2 light yellow seeds in each chamber. The air is rich, spicy and bitter. Chuanwu particles are large and uneven, some have cracked, the color is black and brown, and the aroma is slightly worse. Du Wuyu particles are small, dark green, loose texture and poor aroma. Chang Wu Yu, uniform particles, less cracking, gray green color, strong aroma. The fruit of Evodia rutaecarpa contains about 0.4% volatile oil. The main component in the oil is Evodia rutaecarene, which is a special odor component of the oil and contains Evodiamine lactone, baslerene, Evodiamine alcohol, etc. It also contains Evodia acid. It also contains alkaloids: evodiamine, evodiamine, evodiamine, hydroxyl evodiamine, evodiamine, evodiamine. In addition, it still contains the bitter element of Evodia. Evodia has the effects of stimulating the uterus, analgesia, killing Ascaris suis, inhibiting Staphylococcus aureus, Mycobacterium tuberculosis, and Chloromonas. It also has different degrees of inhibition on a variety of skin fungi. The above information is collected by Xiaonan. |
| main adaptation symptoms | anticancer activity. It has a certain effect in inhibiting the growth of cancer cells. Studies have shown that this component can inhibit the growth of a variety of cancer cell lines, including leukemia cells, cervical cancer cells, breast cancer cells and liver cancer cells. Analgesic and anti-inflammatory effects. Through the experimental study of the vascular permeability of the acetic acid channel, the response to the foot swelling induced by bradykinin and the ear swelling induced by arachidonic acid, it was found that the effect of the blood vessel permeability of the acetic acid channel was obvious. Analgesic and anti-inflammatory effects. Anxiety sedative effect. Insecticidal activity. To dilate blood vessels. Anti-gastric ulcer effect. Through the systematic study of the theory of the nature and taste of Evodia rutaecarpa, it is found that Evodia rutaecarpa polysaccharide and Evodiamine have certain anti-gastric ulcer effects. |
| Main References | [1] Yao Di, Sun Jingjing, Liu Lei, et al. LC-MS/MS Determination of Evodiamine, Evodiamine and Evodiamine in Rat Plasma and Their Bioavailability [J]. Huaxi Journal of Pharmacy, 2014, 29(3). [2] Yang Bingyou, Song Jiaxin, meng Yonghai, et al. Study on the Anti-gastric Ulcer Effect of Evodia Polysaccharide and Evodiamine [J]. Chinese Medicine Information, 2012, 29(3):11-15. [3]http://baike.baidu.com/item/柠檬苦素 |
| biological activity | Evodine is a natural product (derived from Evodia rutaecarpa), which is recorded as a biomarker for quality evaluation of Evodia rutaecarpa in Chinese Pharmacopoeia. Evodine is also an effective inhibitor of P-gp. |
Last Update：2024-04-09 21:32:01
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